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Participant Presenations from the first meeting

Monday, January 17

Session I

Opening Speech: Yoshiyuki Sakaki

Boris N. Kholodenko, “Why do we need a Consortium: What is down the road?

Keynote Speech: Yosef Yarden, "The ErbB/HER Signaling Network: An Interface Between System Biology and Cancer Therapy"

Session II

Hans V. Westerhoff, Frank J. Bruggeman and Jorrit J. Hornberg, "Principles underlying signal transduction"

Boris N. Kholodenko and Jan B. Hoek, "Receptor Tyrosine Kinase Signaling in Time and Space "

Walter Kolch, "Modelling the Raf-MEK-ERK Pathway"

Session III

Alexander Sorkin, "Spatial and Temporal Regulation of EGF Receptor Signaling"

Shigeyuki Yokoyama, "Structural proteomics of RTK signaling"

Session IV

Richard Gallagher, "International Consortia in Biology: How are they organized, who funds them and what is their impact?"

Keynote Speech: Joseph Schlessinger, "Cell signaling by receptor tyrosine kinases; from the bench to the bedside"

Tuesday, January 18

Session V

Frame Agreement for the Consortium (Free Discussion)
  1. How the consortium might be organized
  2. How ambitious will be its mission
  3. Key objectives (standarization, key cell systems etc)

Session VI

Consortium Joint Project Ideas (Free Discussion)

Mariko Hatakeyama, "Breast cancer signaling and gene expression"

Makoto Taiji, "MD simulation for RTK signaling and its application for pharmaceutical development"

Pierre de Meyts, "Towards a Systems Biology of RTK Signal Transduction"

Session VII

Group Meeting based on the interests (Changed to Free Discussion)

Wednesday, January 19

Session VIII

Keynote Speech: Pierre de Meyts, "Understanding RTK Signaling Specificity: Insulin versus IGFs"

H. Steven Wiley, Brian Thrall, Lee Opresko, Galya Orr, Haluk Resat and Douglas Lauffenburger, "The EGFR System Couples Cell Response to Context"

David A. Fell and Frances A. Brightman, "Simulating the EGF Signal Transduction Pathway to Understand Drug Action"

Session IX

Herbert M. Sauro, "An Engineering Perspective on Signaling Pathways"

Reinhart Heinrich, "Dynamics and Design of Signaling Networks: The Wnt-pathway and Regulatory Principles of Protein Kinase/Phosphatase Signaling"

Yu-ichi Ozaki, Kazuhiro Fujita and Shinya Kuroda, "Distinct Dynamics of Transient and Sustained ERK Activation Satoru Sasagawa"

Ulrich Rodeck, Qing Ren, Marlene R. Quadros, Csaba Kari and Adam P. Dicker, "Integration of Signaling Pathways in Complex Environments"

Session X

Hiroaki Kitano, "Closing Talks: Biological Robustness"