PNNL, RIKEN organize RTK Consortium Workshop
Pacific Northwest National Laboratory and RIKEN Genomic Sciences Center, Japan, hosted the first Receptor Tyrosine Kinase (RTK) Networks Consortium Workshop, held October 23 in Boston in conjunction with the International Conference on Systems Biology (ICSB). The RTK Consortium was established in January 2005 to facilitate and coordinate international efforts to understand RTK signaling pathways and their relationships to human pathologies. RTKs are central components of cell signaling networks and play key roles in normal physiological processes.
The objective of the consortium is to facilitate quantitative research on RTK biological networks and to build understanding of RTK systems through quantitative study of RTK pathways as integrated systems. The Consortium members will generate and test hypotheses for the identification and evaluation of therapeutic targets for translational research.
More than 80 scientists from throughout the world attended the October workshop, which included presentations by 10 scientists from the U.S., U.K., Germany, and Japan on work related to the systems biology of RTK signaling (see the program). Steven Wiley, PNNL chief scientist, and member of the Consortium's Executive Committee, gave a talk entitled “The EGFR system couples cell response to context.” After the workshop, Wiley chaired the members-only session.
Photos from the workshop





Michael Blinov and James Faeder, Los Alamos National Laboratory, with Boris Kholodenko, Thomas Jefferson University and RTK Consortium chair.

Consortium president Yoshiyuki Sakaki, RIKEN Genomic Sciences Center , and Executive Committee member Hiroaki Kitano, The Systems Biology Institute.


Bryan Linggi, Vanderbilt University; Executive Committee member Mariko Hatakeyama, RIKEN Genomic Sciences Center; and Haluk Resat, Pacific Northwest National Laboratory.

Hiroaki Kitano with Jan Hoek, Thomas Jefferson University.

RTK Consortium Executive Committee member Steven Wiley, Pacific Northwest National Laboratory, following the RTK Consortium Workshop October 23 in Boston.



